King’s College London "Cannabis extract helps reset brain function in psychosis"

Research from King’s College London has found that a single dose of the cannabis extract cannabidiol can help reduce brain function abnormalities seen in people with psychosis. 

Results from a new MRC-funded trial, published in JAMA Psychiatry, provide the first evidence of how cannabidiol acts in the brain to reduce psychotic symptoms.

Cannabidiol, also referred to as CBD, is a non-intoxicating compound found in cannabis. A purified form of cannabidiol has recently been licensed in the USA as a treatment for rare childhood epilepsies, and a 2017 King’s College London trial has demonstrated cannabidiol has anti-psychotic properties.

However, exactly how cannabidiol may work in the brain to alleviate psychosis has remained a mystery.

“The mainstay of current treatment for people with psychosis are drugs that were first discovered in the 1950s and unfortunately do not work for everyone,” says Dr Sagnik Bhattacharyya, from the Institute of Psychiatry, Psychology & Neuroscience (IoPPN). “Our results have started unravelling the brain mechanisms of a new drug that works in a completely different way to traditional anti-psychotics.”

CBCA (Cannabichromenenic Acid)

Cannabichromenenic acid (CBCA) is found in higher concentrations in young plants, which decreases with maturity, is produced by CBGA in raw cannabis plants. CBCA then goes on to produce other cannabinoids (CBC, CBL, and CBLA) when heated or aged. Like CBDA and THCA, CBCA is the parent cannabinoid of CBC. 

The neutral form of CBCA, Cannabichromene (CBC) binds with receptors that are linked to pain perception and also increase levels of endocannabinoids like anandamide. Also CBCA maybe has anti-fungal and anti-inflammatory properties but more studies must to be proved and have safe results on this.

As we know, anti-inflammatories are great for treating systemic inflammation like arthritis, analgesics are helpful in treating various types of pain, and anti-microbial properties kill harmful microorganisms. 

The CBC has shown potential in treating acne, diarrhea, inflammation of the gastrointestinal tract, swelling, pain, depression, and as an anti-bacterial and anti-fungal agent. One of CBC’s most interesting benefits is that it may actually promote the development of brain cells.

$32,500 for CBD Oil? FDA Wants to Turn CBD Oil Into a Drug???

If we don’t change a key FDA policy, that’s how much you may be forced to pay if you want to purchase CBD oil.

For years, consumers have benefitted from access to cheap, safe, and effective CBD oil supplements. But now the FDA says that CBD is a drug, not a supplement—a drug which will be sold for $32,500 a year. Legally the FDA could at any time remove all CBD supplements from the market, on its own volition, or if the drug company which holds drug market exclusivity requests FDA do so. Unless we change the rules, we may see a government-sponsored monopoly on CBD oil, and in the near future, additional monopolies on other cheap, safe, and effective supplements.

CBGVA (Cannabigerovarinic acid)

Cannabigerovarinic acid (CBGVA) is an naturally occurring compound found in cannabis plant. 'Mother Cannabinoid' is another definition.

CBGVA is a 'building block' for other cannabinoids, like CBGA, through the process of biosynthesis,as the cannabis plant matures, CBGVA produces tetrahydrocannabivarin carboxylic acid (THCVA), cannabidivarinic acid (CBDVA),cannabichromevarinic acid (CBCVA) and other compounds.

Resently remmoved from the SheduleI prohibitions and the information you can find are limited so we don't know enought about the pharmaceutical properties that might have.

But in a study published in Intenational Jurnal Of Oncology, six different cannabinoids were tested including CBGVA .

The study examines the Anticancer effects of phytocannabinoids used with chemotherapy in leukaemia cells can be improved by altering the sequence of their administration

The study suggest that "when certain cannabinoids are paired together, the resulting product can be combined synergistically with common astill remain efficacious. Nevertheless, the sequence of drug administration is crucial to the success of these triple combinations and should be considered when planning such treatments. Anti-leukaemia drugs allowing the dose of the cytotoxic agents to be dramatically reduced yet.

Mabe this is the start for further studies on CBGVA and in all other cannabinoids.

Timeline: Discovering the Endocannabinoid System (Part1: 1964/1995)

"The Process of Discovering the Endocannabinoid System"

Without the research conducted on the cannabis sativa plant that lead to the discovery of the endocannabinoid system, our understanding of the human body's functions would move into the future underdeveloped; unknowing of this system that produces & interacts with cannabinoids that are also found in the plant.

The discovery of the endocannabinoid system didn’t happen overnight. It was a series of events beginning in 1964 with the isolation of THC…