"Use of CBD in the Treatment of Epilepsy: Efficacy and Security in Clinical Trials"

CBD has received a great scientific interest thanks to its medical applications. 

In recent years, the scientific community has shown interest in this compound also due to its good safety profile and neuroprotective properties  in several neurodegenerative diseases.

CBD also generating interest due to its therapeutic properties such as antidepressant, antipsychotic, analgesic, and antitumor. 


In addition, it has been shown that CBD can significantly reduce two important forms of anxiety, namely obsessive-compulsive disorder and post-traumatic stress disorder.

CBD shows anti-inflammatory properties in several experimental studies, modulating some pro-inflammatory cytokines and tumor necrosis factor as well as regulation of cell cycle and immune cells’ functions

Moreover, for a long time, the CBD has been investigated for its anticonvulsant effects. Several studies confirmed its efficacy in the treatment of epileptic seizures, especially in pediatric age. In 2016, the first results of  clinical trials showed beneficial effects of CBD in treatment-resistant seizure disorders, including Lennox-Gastaut Syndrome (LGS) and Dravet syndromes (DS).

The purpose of this paper wich published in  12 April 2019 from the 'Molecules Open Access Journals' is to evaluate the use of CBD, in addition to common anti-epileptic drugs, in the severe treatment-resistant epilepsy through an overview of recent literature and clinical trials aimed to study the effects of the CBD treatment in different forms of epilepsy. 

The results of scientific studies obtained so far the use of CBD in clinical applications could represent hope for patients who are resistant to all conventional anti-epileptic drugs.

Cannabis and endocannabinoid modulators: Therapeutic promises and challenges

The discovery that botanical cannabinoids such as THC exert some of their effect through binding specific cannabinoid receptor sites,has led to the discovery of the Endocannabinoid Signaling System, which in turn has spurred research into the mechanisms of action and addiction potential of cannabis.

This paper reviews current understanding of CB1, CB2, and other possible cannabinoid receptors, their arachidonic acid derived ligands (e.g. anandamide 2 arachidonoyl glycerol), and their possible physiological roles. CB1 is heavily represented in the central nervous system, but is found in other tissues as well CB2 tends to be localized to immune cells. Activation of the endocannabinoid system can result in enhanced or dampened activity in various neural circuits depending on their own state of activation.

This suggests that one function of the endocannabinoid system may be to maintain steady state. The therapeutic action of botanical cannabis or of synthetic molecules that are agonists, antagonists, or which may otherwise modify endocannabinoid metabolism and activity indicates they may have promise as neuroprotectants, and may be of value in the treatment of certain types of pain, epilepsy, spasticity, eating disorders, inflammation, and possibly blood pressure control.

"Study Concluded That CBD Can Help With The Reduction of Breast Cancer Cell Proliferation, Invasion and Metastasis"

The process of metastasis to other tissues of the body is the final and fatal step during cancer progression and is the least understood genetically. 

Despite all currently available treatments, breast cancer is most often incurable once clinically apparent metastases develop.

There is a general consensus in the field of cancer research that targeting multiple pathways that control tumor progression is the best strategy for the eradication of aggressive cancers

It is well known that CBD can modulate specific functions of the immune system and the immune system has an important role in the inhibition of cancer progression.

It was essential to determine whether CBD demonstrates antitumor activity and since CBD has a low toxicity, it would be an ideal candidate for use in combination treatments with additional drugs already used in the clinic. 

"Neuroprotective Effects Of Cannabis" by Sensi Seed

Following on from our recent article on the relationship between cannabis use and stroke, we now investigate the role of cannabinoids in mitigating brain damage caused by traumatic brain injury and ischemic stroke. There is mounting evidence to suggest that their various properties have great therapeutic potential.

-Antioxidative & anti-inflammatory properties

In recent years the evidence for the antioxidative and anti-inflammatory properties of various cannabinoids has become well-established, and our understanding of the role they play in modulating neurotransmission too has grown. Thus, serious consideration is now being given to their potential as neuroprotective agents. Cannabinoids have been shown to prevent neuronal death in acute neuronal injury, including Ischemic Stroke (IS) and Traumatic Brain Injury (TBI), as well as provide symptomatic relief in Multiple Sclerosis (MS), Huntington’s disease, and other chronic neurodegenerative diseases.

"Study Reveals That CBD Reduces Blood Pressure After One Dose"

Preclinical studies show CBD has numerous cardiovascular benefits, including a reduced Blood Pressure (BP) response to stress.

The aim of this study from scientists at Nottingham University was to investigate if and how CBD reduces Blood Pressure (BP) in humans.

In June 2017, scientists at Nottingham University published the research they had conducted earlier in the year. Nine healthy male volunteers were given 600 mg of CBD or placebo in a randomized, placebo-controlled, double-blind, crossover study.

CBD was administered in a singular dose after which the research team monitored changes in blood pressure, stroke volume (the measurement of blood that is pumped from the heart’s left ventricle) and heart rate.

All of the study’s participants took part in an exercise test and another stress test using cold temperatures. This allowed researchers to measure cardiac responses under different circumstances.

"Cannabis and Breast Cancer"

Breast Cancer Awareness Month

Every October, people all over the world show their support for everyone affected by breast cancer.Worldwide, breast cancer is the leading type of cancer in women, accounting for 25% of all cases. It is more common in developed countries and is more than 100 times, more common in women than in men.

Breast cancer is cancer that develops from breast tissue. Signs of breast cancer may include a lump in the breast, a change in breast shape, dimpling of the skin, fluid coming from the nipple, a newly inverted nipple, or a red or scaly patch of skin. In those with distant spread of the disease, there may be bone pain, swollen lymph nodes, shortness of breath, or yellow skin.

Patient surveys have provided important insights about how people use medical cannabis. About 42% of people diagnosed with breast cancer who completed a survey for breastcancer.org said that they used medical cannabis products to manage breast cancer symptoms or treatment side effects. People who used medical cannabis ranged in age, cancer stage, and treatment phase, and most of them they found it to be “very” or “extremely” helpful.(75%)

"Cannabis and Cancer"

Cancer is the holy grail of medical research and it’s the most-coveted breakthrough of our time. (and the most profitable disease). 

If we could discover a way to prevent malignant cells from effect in the human body, not only would we save millions of lives, but we would end years of suffering and, we could finally feel superior from this illness.

But, is Cannabis a way that we can achive this?

Studies, so far, show that cannabis can kill all types of cancer cells, reduce angiogenesis and prevent from metastasis

One Treatment Doesn’t Fit All...

Cancer isn’t just one thing. It’s an umbrella term for a collection of related illnesses. What unites these is the method of mayhem: cancer divides and spreads like ants at a picnic. And because it’s not just one kind of ant, we’ve developed slightly different ways to deal with each species.

Standard cancer treatment must be adapted to the type and location of tumor. When cancer infects the brain, we can’t necessarily handle it the way we would handle cancer in the stomach. Even if the same treatments would effective at stopping the cancer, the collateral damage to brain cells is just too risky.

Although human trials and solid scientific research are still a ways off, early studies indicated that cannabis might be the one truly universal way to kill cancer cells and while chemotherapy and radiation have certainly helped humanity’s battle against cancer, research into the endocannabinoid system keeps new information about how cannabis can to prevent tumors to form, spread and turn deadly.

"The Begining of Western Medicine"

Our little story begins from the Middle Ages and with two powerful and very profitable products... Opium & Oil.

In 1803 Friedrich Sertuerner  discovers an active ingredient in opium which if you dissolved in acid and then neutralizing it with ammonia result of this is... Morphine. 

Morphine was not only the first alkaloid to be extracted from opium, but the first ever alkaloid to be isolated from plant. 

In 1827 E. Merck & Company of Darmstadt, begins the commercial manufacturing of morphine for healing purposes.  It would become a dominant manufacturer of morphine, codeine and cocaine.

When we think of Bayer we think of aspirin, definitly not heroin.... but in 1895 Bayer Company of Elberfeld, finds that diluting morphine with acetyls produces a drug without the common morphine side effects and the name for this new compound... Heroin   
  
And where you find acetyls to produce heroin?  Where did the acetyls come from?  Well, just like today they come from petrochemicals, and sudenly all this led us to a name.... "John D. Rockefeller" the oil baron... 

How To Use CBD For Unbelievable Sleep

These days, it is almost impossible for people to “turn off” between constant smartphone connection and rising digital social pressures, rates of insomnia and other sleep-related disorders 

Whether you toss and turn all night, or lay there thinking about the problems of the day, it can be frustrating not getting great sleep, especially if you’ve tried all of the things that are supposed to help:

• Exercising during the day
• “Winding down” an hour before bed
• Not consuming caffeine beverages in the afternoon
• Going to bed at the same time every night, with the same routine
• Stop drinking alcohol
• Creating a super dark room with blackout shades
• Putting in ear plugs
• Turning on the blue-light filter on your phones or putting away your devices completely before bed-time
• And every vitamin, supplement, and herb out there!

The fact is, sometimes you still can’t get a good night’s sleep. It’s not your fault there’s something bigger going on.

If you don’t want to resort to prescription medications, then CBD could be the answer you’ve been waiting for. It does absolutely jaw-dropping things to your sleep because of its many wonderful medicinal properties.

It can stop the racing thoughts, help you calm down and finally get the kind of deep, restorative sleep you’ve been dreaming about for YEARS. In this mega-guide, we’re going to show you how.

"CANNABIS & SPIRITUALITY"

The stoner stereotype is a familiar one that transcends cultures...

But as legalization allows cannabis to be discussed maturely, that trope seems like a dying remnant of the decades-long smear campaign against a plant that can truly impact our lives, culture, and economy in a positive way. 

With the relaxation of Cannabis stigma, people can explore a path of spirituality, studying the plant’s use as a tool for inner exploration and enlightenment.

Much like any other psychedelic substance, cannabis can be abused and consumed without respect to its potency, power, or healing potential. Certainly, there’s no harm in using it as a tool to relax and decompress from life’s daily stresses, but some might argue there’s a point of diminishing return when consuming copious amounts without setting the right intention.

And for religions that consider the plant sacred, this is typically their view on the use of cannabis — using it heedlessly is considered a sin or frowned upon, while using it for enlightenment or spirituality is accepted, and in some cases, encouraged.

"Prescription of a THC/CBD-Based Medication to Patients with Dementia: A Pilot Study in Geneva"

Dementia is characterized by a deterioration in memory, thinking, behavior, and autonomy in daily life activities. 

According to the World Health Organization, there were around 50 million persons worldwide suffering from dementia and this number is increasing with the global aging of the population in most countries. 

Currently, the options for treating BPSD (Behavioral and Psychological Symptoms of Dementia) include pharmacological and nonpharmacological therapies. Psychotropic medications are often used to reduce the frequency and severity of BPSD, but in the majority of patients, they provide only modest symptom control and important side effects.

The interest of cannabinoids in Alzheimer disease and other forms of dementia has increased first as neuroprotective drugs in animal studies. Indeed, some studies suggest a potential beneficial effect of CB1 and CB2 receptor agonists on reducing harmful β-amyloid peptide action and tau phosphorylation seen in Alzhei­mer disease as well as increasing intrinsic brain repair mechanisms.

"Finally... is CBD Better Than Aspirin...?

Probably if you search on internet you will find many post's wich claims that CBD is better or stronger than Aspirin. 

And probably you are so quite sure about the safety of Aspirin, in  point that you may be laugh...

So, lets take a closer look to Aspirin and to CBD and lets see what we will find out!!!


Aspirin, also known as acetylsalicylic acid (ASA), is a medication used to treat pain, fever, or inflammation. Specific inflammatory conditions which aspirin is used to treat include Kawasaki disease, pericarditis, and rheumatic fever.Aspirin given shortly after a heart attack decreases the risk of death. Aspirin is also used long-term to help prevent further heart attacks, ischaemic strokes, and blood clots in people at high risk. It may also decrease the risk of certain types of cancer, particularly colorectal cancer. 

"The most of us we dont know exactly how many adverse effects has this 'innocent' pill..."

"New compound from CBDA could be substitute for opioids & steroids"

Israeli researcher Raphael Mechoulam has announced the development of a process to modify and stabilize cannabidiolic acids (CBDA) that appear early in the cannabis plant’s growth, rendering compounds that have the potential for large-scale use.

The result is a semi-synthetic, fully stable, acid-based compound that could be useful in suppressing nausea from chemotherapy, and be a treatment for such afflictions as Inflammatory Bowel Disease (IBD) and Psoriasis. 

Researchers say such compounds, which are more potent than CBD or THC – and which so far have shown no negative side effects – could replace steroids and opioids.

Politically correct for pharma

Mechoulam worked with American biotech startup EPM to develop the solution to stabilizing the acids through esterification, a simple chemical process. That could prove interesting to the pharmaceutical industry as the process turns out the acids in a consistent form that is patentable. Also, EPM CEO Reshef Swisa said the U.S. Food and Drug Administration has told the company the compound would not be treated as cannabis but as any other drug in development, thereby avoiding the stigma and legal limitations associated with marijuana.

"Cannabis & Chemotherapy Side Effects"

When it comes to chemotherapy, medical cannabis is primarily used to treat the common side effects including nausea, vomiting, loss of appetite and pain. 

Here’s what you need to know about how medical cannabis can support you or a loved one during chemo. 

The 2 majors cannabinoids THC & CBD have shown to effectively reduce the nausea and vomiting that often occurs during and after chemotherapy treatments.

For example, THC seems to cause the "high" reported by marijuana users, and also can help relieve pain and nausea, reduce inflammation, and can act as an antioxidant.

Cannabidiol (CBD) can help treat seizures, can reduce anxiety and paranoia, and can counteract the "high" caused by THC.

In this point, you will allow me to emphasize that the researches about cannabis & chemotherapy so far suggests that it is the synergy of all cannabinoids together that has the greatest results for patients but lets see what the experts say about it...

"Cannabis & Chronic Wounds"

A chronic wound is a wound that does not heal in an orderly set of stages and in a predictable amount of time. 

Wounds that do not heal within 3 months are often considered as 'Chronic Wound'.

Chronic wounds seem to be detained in one or more of the phases of wound healing.For example, chronic wounds often remain in the inflammatory stage for too long. To overcome that stage and jump-start the healing process a number of factors need to be addressed such as bacterial burden, necrotic tissue, and moisture balance of the whole wound.

Chronic wounds may never heal or may take years to do so. These wounds cause patients severe emotional and physical stress and create a significant financial burden on patients and the whole healthcare system.

Most therapists may use topical antibiotics, which kill bacteria and can also help by keeping the wound environment moist, which is important for speeding the healing of chronic wounds. Some researchers have experimented with the use of tea tree oil, an antibacterial agent which also has anti-inflammatory effects.

The ideal methods of pain relief for wound patients are modalities that are topical, lack systemic side effects, noninvasive (not requiring the introduction of instruments into the body), self-administered, and display rapid onset of analgesia.

Extracts derived from the cannabis plant have been applied to wounds and other dermatological problem for thousands of years...

"Cannabis & Alzheimer's Desease"

Alzheimer's disease (AD) is a neurological disorder of unknown origin that is characterized by a progressive loss of memory and learned behavior. For both patients and their loved ones, Alzheimer’s Disease ranks among the most challenging conditions one can experience.

This chronic neurodegenerative disorder leads to progressive symptoms including dementia, memory loss, emotional issues, and speech problems, among others. Few treatments exist and available therapies only address some symptoms, but not the progression of the disease itself.

The search for new therapeutic options has led to significant interest in cannabis-based treatments and researchers are currently working to advance our understanding of the possible roles medical cannabis could play in the future of Alzheimer’s treatment.

Preclinical data shows the potential of cannabinoids to moderate the progression of AD while clinical data demonstrates that these compounds can provide symptom relief, but lets take a look in what 10 studies says about it...