"Cannabinoids & Glioblastoma Therapy"

Glioblastoma (GBM) is the most malignant brain tumor and one of the deadliest types of solid cancer overall. More than 95% of GBM patients die within 5 years after diagnosis. Accumulating evidence indicates that cannabinoids have potent anti-tumor functions.

Glioblastoma...

Half of newly-diagnosed gliomas are glioblastomas (GBMs), with an incidence in adults of 0.59 3.69 cases per 100,000 person life-years. Primary GBM occur more commonly in male patients whereas the reverse is the case for secondary GBM. The mean age of primary and secondary G BM patients is 62 and 45 years, respectively (Adamson et al., 2009).

Cannabinoids...

The term cannabinoids originally described bioactive constituents of the plant Cannabis sativa. The cannabis ingredients were used traditionally for their medicinal purpose but also for their recreational properties. Most of the cannabinoids bind to G-protein coupled cannabinoid receptors, CB1 and CB2, and act as agonists or inverse agonists.

"Industrial Hemp,Agronomy and Ultilization"

There are increased interests in growing grain and fiber hemp (Cannabis sativa L.) as well as in large-scale hemp products. Cannabis has been grown/ utilized for thousands of years as a fiber, grain, and medicinal plant. 

However, the strict control of cannabis cultivation to combat illegal use, the spread of new yarns and oilseeds, and the advent of cheap synthetic fibers caused a decreased/eliminated hemp production

Hemp has a long history of being used for fiber, grain, and medicinal purposes, but its cultivation has been strictly controlled due to concerns about illegal drug use, competition from synthetic fibers, and bans in many countries.

However, with the legalization of hemp in the USA through the 2014 and 2018 Farm Bill, research programs have been launched by universities to explore its potential. Hemp has the advantage of being a versatile crop that can be used for multiple purposes, creating opportunities for the market to value hemp products.

This paper, published on MDPI Open Access Jurnals, highlights that hemp has the potential to be a sustainable and environmentally friendly crop, with its ability to absorb heavy metals, sequester carbon, and suppress weeds without the use of pesticides. The paper aims to examine the historical and recent literature on hemp agronomy and utilization, focusing on industrial hemp for grain and fiber production.

"The Effectivenes of Medicinal Cannabis in Adults with Non-Cancer Diagnoses"

This research conducted through a retrospective medical record review aimed to describe the characteristics and effectiveness of medicinal cannabis use in adults with non-cancer diagnoses in Australia. 

People with chronic conditions may benefit from using medicinal cannabis for treating chronic pain, multiple sclerosis, Parkinson’s and other conditions. 

The study reviewed 157 medical records, with the majority of patients were predominantly female (63.7%), aged 63.0 years, and from the Greater Sydney region (86.6%). Most patients were born in Australia (66.9%) , with 17.8% stating previous cannabis use and having neurological (58.0%) or musculoskeletal (24.8%) conditions.

The findings showed that 53.5% of patients perceived medicinal cannabis to be beneficial. Significant changes over time were observed in various symptom assessments, including pain, bowel problems, fatigue, difficulty sleeping, mood, quality of life (QoL), breathing problems, and appetite.