However, with increasing use, there is a worrying increase in reports of adverse cardiovascular events after marijuana exposure.
Based on the limited published data, authors hypothesized that marijuana use would be associated with worse in-hospital results in patients with Acute Myocardial Infarction (AMI).
Few studies, however, have examined the impact of marijuana use on cardiovascular outcomes such as AMI and are limited by small sample sizes but a study aimed at quantitating long-term effects for marijuana users after AMI showed no correlation between marijuana consumption and long-term mortality in patients after AMI.
The purpose of this retrospective study is to quantify short-term outcomes in AMI patients with reported marijuana use to those with no reported marijuana use.
The researchers compared the results of AMI patients in the hospital with reported marijuana use to those who did not report marijuana use.
In total, 3,854 of 1,273,897 AMI patients reported using marijuana.
Methods and Materials...
Clinical profiles and results in patients with reported marijuana use were compared with patients without reported marijuana use.- Short-term outcomes were defined as adverse events that occurred during hospitalization for an acceptable AMI diagnosis.
-The composite primary outcome included death, IABP, mechanical ventilation, cardiac arrest and shock.
-Secondary results included the individual components of the primary outcome, coronary angiogram, transdermal coronary intervention and STEMI vs. NSTEMI.
Main Findings of This Study :
- Patients with reported marijuana use had a lower incidence of in-hospital mortality than those who did not report marijuana use
-Marijuana patients were more likely to be mechanically ventilated during their stay in a hospital compared to users non-marijuana but the risk of mechanical ventilation was significantly higher in patients reporting the use of both tobacco and marijuana compared to those who reported only the use of marijuana.
-Marijuana use was associated with significantly lower odds of death in patients admitted with STEMI (ST-Elevation Myocardial Infarction) whereas there was no association between marijuana use and mortality in the NSTEMI (Non-ST-elevation myocardial infarction) group.
In both STEMI and NSTEMI groups, patients with marijuana use were less likely to receive PCI (Percutaneous Coronary Intervention, formerly known as angioplasty with stent) than patients who did not use marijuana.
-The average admission age for AMI was on average 10 years younger for marijuana users versus non-users,but dont forget that patients reporting the use of both tobacco and marijuana.
Conclusion...
Perhaps the most striking finding of the study is that the use of marijuana prior to AMI was associated with reduced morbidity in the hospital after AMI.
A possible explanation for the mortality benefit seen in this study is that marijuana use may have provided a cardioprotective effect to users.
While small clinical studies have previously suggested worse AMI outcomes associated with marijuana use, there is evidence that marijuana could be protective in the setting of myocardial ischemia.
Given the increasing prevalence and acceptance of marijuana use, these findings suggest that additional study is warranted to further investigate these discoveries and to identify potential mechanisms by which marijuana is associated with improved short-term outcomes following AMI and for mitigating the possible negative effects of concomitant substance use.
Source : https://journals.plos.org
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