We know that omega-3 acids are useful to the ECS for two reasons.
A, it helps the cannabinoid receptors to be more active.
B, those omega-3s and phospholipids are used as backbone structures to produce cannabinoids in the body.
B, those omega-3s and phospholipids are used as backbone structures to produce cannabinoids in the body.
We also know that Omegas they have anti-inflammatory benefits but a study reveals the cascade of chemical reactions that converts omega-3 fatty acids into endocannabinoids...
"Cannabis oil or foods such as meat, eggs, fish and nuts contain omega-3,-6,-9 fatty acids, which the body converts into endocannabinoids: said Aditi Das, a University of Illinois professor of comparative biosciences and biochemistry, who led the study.
"Cannabinoids in Cannabis plant and endocannabinoids produced in the body can support the body's immune system and therefore are attractive targets for the development of anti-inflammatory therapeutics" she said.
"Cannabis oil or foods such as meat, eggs, fish and nuts contain omega-3,-6,-9 fatty acids, which the body converts into endocannabinoids: said Aditi Das, a University of Illinois professor of comparative biosciences and biochemistry, who led the study.
"Cannabinoids in Cannabis plant and endocannabinoids produced in the body can support the body's immune system and therefore are attractive targets for the development of anti-inflammatory therapeutics" she said.
In 1992 researchers discovered endocannabinoids produced naturally in the body. Since then, several other endocannabinoids have been identified, but not all have known functions.Some cannabinoids can bind to these receptors and elicit anti-inflammatory and anti-pain action.
Researchers discovered an enzymatic pathway that converts omega-3-derived endocannabinoids into more potent anti-inflammatory molecules that predominantly bind to the receptors found in the immune system.
"This finding demonstrates how omega-3 fatty acids can produce some of the same medicinal qualities as cannabis, but without a psychotropic effect."
-How omega-3 fatty acids affect our cells...
Despite numerous published dietary and clinical studies, we still don't fully understand how omega-3 fatty acids affect our cells and if this varies from person to person, between healthy and ill individuals, or whether the mechanism of action varies in different tissues and cells.
What we are most sure of is that omega-3 fatty acids can dampen inflammatory reactions. Inflammatory reactions are very important in combating infections, but they can be harmful if activated too strongly or in the absence of bacteria and viruses, like in autoimmune diseases and organ transplants.
Macrophages, which are immune cells that live in all tissues and organs, play a key role in coordinating inflammatory reactions in the body and monitor everything that happens in our tissues. The macrophages convert the information they obtain through various sensors or receptor on their surface to secretion of various hormone-like signal substances that control all parts of inflammatory reactions.
-Activates self-cleaning process...
By studying macrophages, we found that the omega-3 fatty acids activated the autophagy and specifically affected some proteins that transform the signals from the environment. Furthermore, we found that omega-3 fatty acids dampened many inflammatory mechanisms within the macrophages, but especially reduced what is known as the type 1 interferon response.
The factor CXCL-10, which macrophages secrete as part of this interferon response following many types of stimuli, was the most clearly reduced factor after adding omega-3 to the cells.
We then examined blood samples from a clinical study in cardiac transplant patients where we knew that omega-3 supplements improved their clinical status. In these cases, we found that omega-3 fatty acids reduced the level of CXCL-10.
By studying macrophages isolated from mice and humans, we found that the omega-3 fatty acids activated the autophagy and specifically affected some proteins that transform the signals from the environment. Furthermore, we found that omega-3 fatty acids dampened many inflammatory mechanisms within the macrophages, but especially reduced what is known as the type 1 interferon response.
The factor CXCL-10, which macrophages secrete as part of this interferon response following many types of stimuli, was the most clearly reduced factor after adding omega-3 to the cells.
We then examined blood samples from a clinical study in cardiac transplant patients where we knew that omega-3 supplements improved their clinical status. In these cases, we found that omega-3 fatty acids reduced the level of CXCL-10.
These findings indicate that omega-3 fatty acid supplements may be particularly beneficial in patients who have conditions that are driven or aggravated by a strong interferon response and CXCL-10.
Researchers hopes that those findings, one day will benefit patients with different forms of cancer, meningitis, multiple sclerosis, Alzheimer's disease or jaundice. But we must emphasize that a lot of work remains.
-Hemp seed oil and Omega-3...
Hemp seed oil is composed of nearly 85 percent essential fatty acids (EFAs) alone and offers the richest, most balanced natural source of EFAs. In fact the amount of alpha-linolenic and linolenic acid in 15 ml (one tablespoon) of hemp seed oil provides more than the daily EFA requirements suggested by the FDA.
In addition, hemp seed oil is lower in saturated fatty acids than other comparable oils, is easily digested and has been shown to alleviate symptoms of atopic dermatitis (eczema) and even psoriasis.Hemp seed oil also exhibits the highest total phenolic content and antioxidant activity compared to all other plant-based oils (with the exception of pumpkin seed oil). Naturally occurring phenolic compounds are known to play a key roll in reducing the risk of cancer, relieving systemic inflammation, acting as a powerful antioxidant and promoting free radical elimination.
Chemo-preventive (anticarcinogenic) properties of hemp seed oil work by causing apoptosis (cell death), inhibiting the cell cycle and preventing the abnormal proliferation of cells characteristic of cancerous tumors.
In addition to being safe to consume, hemp seed oil is more sustainable than fish oil because it does not upset ocean ecosystems and reduce sizable fish populations necessary to support fish living in the upper areas of the food chain. In addition, hemp plants are pest and disease resistant, help reduce greenhouse gases in the atmosphere and provide hemp seeds from which we can cold-press versatile, nutritious and eco-friendly hemp seed oil.
-Foods With Omega 3...
Omega 3 fatty acids are polyunsaturated, which have a double bonded structure. Our bodies do not produce these naturally. So, we must source all our omega 3 from dietary sources. A diet with the right amount of omega 3 is beneficial to bone health, heart health, and weight loss.
The best places to source healthy omega 3 fatty acids are from:
Oily fish (salmon, sardines, mackerel), chia seeds, and flaxseeds.
-Foods With Omega 6...
This is another essential fatty acid, and another polyunsaturated one. Once metabolized, omega 6 tends to turn into pro-inflammatory compounds. A diet too high in omega 6 may increase the risk of inflammatory disease. This is the issue with junk foods!
Instead of sourcing all your omega 6 from unhealthy processed foods, look for omega 6 in the following healthy sources (consumed in moderation):
Soybeans, walnuts, sunflower, almonds, and walnuts.
-Foods With Omega 9...
This question is a bit of a riddle. Omega 9 fatty acids are monounsaturated. Unlike omega 6 and 3, omega 9 is a non-essential fatty acid. Our bodies naturally produce enough for us to function. That said, we may all benefit from a dietary boost in omega 9. Research shows that by boosting our omega 9 fatty acid intake, we can reduce inflammation, improve insulin sensitivity, and improve metabolic health.
Boost your omega 9 intake by adding these foods into your diet:
Olive oil, cashews, avocado, almonds, and walnuts.
Sourcing healthy foods rich in omega 3-6-9 promotes a beneficial “cascade of chemical reactions” in our bodies. With the right balance, and omega 3, in particular, we can improve our body’s natural cannabinoid production and function.
Further research may also find that combining phytocannabinoids (from plants like cannabis) with omega 3 improves cannabinoid function as well. With a little more study, we could find that the anti-inflammatory characteristics of CBD and omega 3 fatty acids are a one-two-punch for fighting inflammatory diseases.
No comments:
Post a Comment