"Study Reviews The Effects of Cannabinoids in Glioblastoma Therapy"

This review article summarizes the latest findings on the molecular effects of cannabinoids on GBM, both in vitro and in (pre-) clinical studies in animal models and patients.
These findings underline the importance of elucidating the full pharmacological effectiveness and the molecular mechanisms of the cannabinoid system in GBM pathophysiology.
The therapeutic effect of cannabinoids is based on reduction of tumor growth via inhibition of tumor proliferation and angiogenesis but also via induction of tumor cell death. Additionally, cannabinoids were shown to inhibit the invasiveness and the stem cell-like properties of GBM tumors.Recent phase II clinical trials indicated positive results regarding the survival of GBM patients upon cannabinoid treatment. 

What is Glioblastoma?

Glioblastoma (GBM) is the most malignant brain tumor and one of the deadliest types of solid cancer overall. GBM is an extremely aggressive type of cancer. These tumors are characterized by high cellular proliferation and angiogenesis resulting in rapid tumor growth and, consequently, necrosis. GBM cells also exhibit high migration and invasive properties, which allow them to produce metachronous lesions and even to spread through the brain parenchyma. Furthermore, GBM tumors contain a subpopulation of glioma stem-like cells (GSCs), which, at least partially, account for the high resistance to therapy and recurrence rates of these tumors.

"Can CBD Help You With Hangovers"?

Family gatherings, company work parties, and holiday celebrations with friends can lead to drinking more than you typically might…which can make you feel like death the following day... and if you don’t normally drink, even 2-3 drinks can make you feel like terrible the next day.  

Let’s not forget that alcohol is basically poison. Not to knock a fun night of drinking or getting your drink on during the holidays, but alcohol consumption can do some serious damage to the brain and body…especially if you’re a heavy drinker.

What Causes Hangovers?

Alcohol is literally poisonous to the human body. It's your liver's job to filter that poison out of your bloodstream. When your liver is working overtime to filter toxins it can cause your blood sugar to drop to dangerously low levels making you feel sick and tired all over. On top of that, alcohol causes dehydration resulting in low electrolytes. Dehydration can cause severe headaches. 

"Clinical Study Assessing Hemp-Derived Cannabinoid Supplementation In Recovery From Traumatic Brain Injury Begins"

The Flowering HOPE Foundation and Clover Leaf University have just announced sponsorship and collaboration on the first US clinical study to be approved to investigate plant-derived cannabinoid supplements in recovery from brain injury. 

The study will analyze quantitative EEG brain activity and a cannabinoid-sensitive salivary biomarker in 40 subjects with mild traumatic brain injury and controls who currently take hemp-derived botanical supplements on a regular basis (i.e. phytocannabinoids).The study is recruiting adults age 18 to 55 to participate in the year-long trial.

"Cannabis Can be Used As An Effective Alternative to Traditional Anti-Anxiety Medications"

"Researchers discovered that nearly half of patients discontinued their use of anti-anxiety meds after starting with medical cannabis"

Findings in a new study published in Cannabis and Cannabinoid Research suggest that cannabis can be used as an effective alternative to traditional anti-anxiety medications.

A team of Canadian researchers assessed the relationship between cannabis and benzodiazepines, a class of drugs that work in the central nervous system and are primarily used for treating anxiety. Common benzodiazepines include Xanax, Ativan, and Valium.

"Neurological Aspects of Medical Use of Cannabidiol"

The aim of this review from NCBI was to describe the state of art about the pre-clinical research, the potential use and when existing, the clinical evidence related to CBD in the neurological field. 

It is important to notice that in this research, 6 Italian

university departments took part 

BACKGROUND:

Cannabidiol (CBD) is among the major secondary metabolites of Cannabis devoid of the delta-9-tetra-hydrocannabinol psychoactive effects. It is a resorcinol-based compound with a broad spectrum of potential therapeutic properties, including neuroprotective effects in numerous pathological conditions. CBD neuroprotection is due to its antioxidant and antiinflammatory activities and the modulation of a large number of brain biological targets (receptors, channels) involved in the development and maintenance of neurodegenerative diseases.