"CBD & Seizures in Lennox–Gastaut syndrome"

 

Researchers provide further evidence that the cannabis compound, CBD, is effective at reducing seizures in people with epilepsy.

The new study reveals CBD significantly reduced seizures in people with Lennox-Gastaut syndrome. Previously, the researchers demonstrated CBD was effective at seizure control in Dravet syndrome.

Cannabidiol (CBD), a compound derived from the cannabis plant that does not produce a “high” and has been an increasing focus of medical research, was shown in a new large-scale, randomized, controlled trial to significantly reduce the number of dangerous seizures in patients with a severe form of epilepsy called Lennox–Gastaut syndrome.

In the new study comparing 2 doses of CBD to a placebo, the researchers reported a -41.9% reduction in “drop seizures” (a type of seizure that results in severe loss of muscle control and balance) in patients taking a 20 mg/kg/d CBD,
-a 37.2 percent reduction in those on a 10 mg/kg/d CBD and
-17.2 percent reduction in a group given a placebo.

“This new study adds rigorous evidence of cannabidiol’s effectiveness in reducing seizure burden in a severe form of epilepsy and, importantly, is the first study of its kind to offer more information on proper dosing,”
says Dr. Devinsky.

CBD & Yoga "A Perfect Combination"

Yoga’s mind-body-spirit connection makes it popular for men and women of all ages. It teaches us to become more present with our bodies and breathing while enhancing our physical health.

But have you ever been in the middle of a yoga class and wondered why you can’t silence your thoughts???

CBD and practicing yoga together is not a new idea. In fact, the ancient Indian sacred texts of the Vedas count cannabis as one of the 5 sacred plants.

It seems like a natural fit – because the benefits of practicing Yoga and taking CBD separately are very similar – reduced stress, lower inflammation, and increased feelings of wellbeing and when taken together, they uniquely complement each other.

Yoga has been seeing an increase in popularity for many decades now, and cannabidiol is swiftly catching up. With virtually no side effects and excellent synergy, combining the two could be what you need to take your daily exercise routine to the next level of wellness.

"Cannabidiol as effective as antipsychotic meds with fewer side effects".

Schizophrenia is a mental disorder that affects a person’s ability to think, feel, and behave clearly. 

It can cause psychotic episodes, and treatment is usually lifelong and involves antipsychotic medications with toxic side effects.

In 2012, researchers published a study in Translational Psychiatry showing that a CBD isolate can treat schizophrenia as effectively as antipsychotic pharmaceuticals — and with far fewer side effects.

In this study, researchers led by Markus Leweke, MD, of the University of Cologne in Germany recruited 39 people with schizophrenia who were hospitalized for a psychotic episode.

"SAFE & LEGAL ACCESS TO MEDICAL CANNABIS AND CANNABIDIOL (CBD)"

While not everyone with epilepsy should or would consider medical cannabis or cannabidiol (CBD) as a treatment option, some people living with uncontrolled seizures have reported beneficial effects and reduced seizure activity when using medical cannabis, especially strains rich in CBD. Further research is needed on the effects of medical cannabis on epilepsy, but when recommended by a treating physician, medical cannabis may be the best alternative for some individuals living with drug-resistant epilepsy and uncontrolled seizures.

Access to medical cannabis will support increased research efforts and allow individuals who have failed to gain seizure control an option for treatment.

"Use of CBD in the Treatment of Epilepsy: Efficacy and Security in Clinical Trials"

CBD has received a great scientific interest thanks to its medical applications. 

In recent years, the scientific community has shown interest in this compound also due to its good safety profile and neuroprotective properties  in several neurodegenerative diseases.

CBD also generating interest due to its therapeutic properties such as antidepressant, antipsychotic, analgesic, and antitumor. 


In addition, it has been shown that CBD can significantly reduce two important forms of anxiety, namely obsessive-compulsive disorder and post-traumatic stress disorder.

CBD shows anti-inflammatory properties in several experimental studies, modulating some pro-inflammatory cytokines and tumor necrosis factor as well as regulation of cell cycle and immune cells’ functions

Moreover, for a long time, the CBD has been investigated for its anticonvulsant effects. Several studies confirmed its efficacy in the treatment of epileptic seizures, especially in pediatric age. In 2016, the first results of  clinical trials showed beneficial effects of CBD in treatment-resistant seizure disorders, including Lennox-Gastaut Syndrome (LGS) and Dravet syndromes (DS).

The purpose of this paper wich published in  12 April 2019 from the 'Molecules Open Access Journals' is to evaluate the use of CBD, in addition to common anti-epileptic drugs, in the severe treatment-resistant epilepsy through an overview of recent literature and clinical trials aimed to study the effects of the CBD treatment in different forms of epilepsy. 

The results of scientific studies obtained so far the use of CBD in clinical applications could represent hope for patients who are resistant to all conventional anti-epileptic drugs.

"Study Concluded That CBD Can Help With The Reduction of Breast Cancer Cell Proliferation, Invasion and Metastasis"

The process of metastasis to other tissues of the body is the final and fatal step during cancer progression and is the least understood genetically. 

Despite all currently available treatments, breast cancer is most often incurable once clinically apparent metastases develop.

There is a general consensus in the field of cancer research that targeting multiple pathways that control tumor progression is the best strategy for the eradication of aggressive cancers

It is well known that CBD can modulate specific functions of the immune system and the immune system has an important role in the inhibition of cancer progression.

It was essential to determine whether CBD demonstrates antitumor activity and since CBD has a low toxicity, it would be an ideal candidate for use in combination treatments with additional drugs already used in the clinic. 

"Study Reveals That CBD Reduces Blood Pressure After One Dose"

Preclinical studies show CBD has numerous cardiovascular benefits, including a reduced Blood Pressure (BP) response to stress.

The aim of this study from scientists at Nottingham University was to investigate if and how CBD reduces Blood Pressure (BP) in humans.

In June 2017, scientists at Nottingham University published the research they had conducted earlier in the year. Nine healthy male volunteers were given 600 mg of CBD or placebo in a randomized, placebo-controlled, double-blind, crossover study.

CBD was administered in a singular dose after which the research team monitored changes in blood pressure, stroke volume (the measurement of blood that is pumped from the heart’s left ventricle) and heart rate.

All of the study’s participants took part in an exercise test and another stress test using cold temperatures. This allowed researchers to measure cardiac responses under different circumstances.

"Cannabis and Breast Cancer"

Breast Cancer Awareness Month

Every October, people all over the world show their support for everyone affected by breast cancer.Worldwide, breast cancer is the leading type of cancer in women, accounting for 25% of all cases. It is more common in developed countries and is more than 100 times, more common in women than in men.

Breast cancer is cancer that develops from breast tissue. Signs of breast cancer may include a lump in the breast, a change in breast shape, dimpling of the skin, fluid coming from the nipple, a newly inverted nipple, or a red or scaly patch of skin. In those with distant spread of the disease, there may be bone pain, swollen lymph nodes, shortness of breath, or yellow skin.

Patient surveys have provided important insights about how people use medical cannabis. About 42% of people diagnosed with breast cancer who completed a survey for breastcancer.org said that they used medical cannabis products to manage breast cancer symptoms or treatment side effects. People who used medical cannabis ranged in age, cancer stage, and treatment phase, and most of them they found it to be “very” or “extremely” helpful.(75%)

How To Use CBD For Unbelievable Sleep

These days, it is almost impossible for people to “turn off” between constant smartphone connection and rising digital social pressures, rates of insomnia and other sleep-related disorders 

Whether you toss and turn all night, or lay there thinking about the problems of the day, it can be frustrating not getting great sleep, especially if you’ve tried all of the things that are supposed to help:

• Exercising during the day
• “Winding down” an hour before bed
• Not consuming caffeine beverages in the afternoon
• Going to bed at the same time every night, with the same routine
• Stop drinking alcohol
• Creating a super dark room with blackout shades
• Putting in ear plugs
• Turning on the blue-light filter on your phones or putting away your devices completely before bed-time
• And every vitamin, supplement, and herb out there!

The fact is, sometimes you still can’t get a good night’s sleep. It’s not your fault there’s something bigger going on.

If you don’t want to resort to prescription medications, then CBD could be the answer you’ve been waiting for. It does absolutely jaw-dropping things to your sleep because of its many wonderful medicinal properties.

It can stop the racing thoughts, help you calm down and finally get the kind of deep, restorative sleep you’ve been dreaming about for YEARS. In this mega-guide, we’re going to show you how.

"Finally... is CBD Better Than Aspirin...?

Probably if you search on internet you will find many post's wich claims that CBD is better or stronger than Aspirin. 

And probably you are so quite sure about the safety of Aspirin, in  point that you may be laugh...

So, lets take a closer look to Aspirin and to CBD and lets see what we will find out!!!


Aspirin, also known as acetylsalicylic acid (ASA), is a medication used to treat pain, fever, or inflammation. Specific inflammatory conditions which aspirin is used to treat include Kawasaki disease, pericarditis, and rheumatic fever.Aspirin given shortly after a heart attack decreases the risk of death. Aspirin is also used long-term to help prevent further heart attacks, ischaemic strokes, and blood clots in people at high risk. It may also decrease the risk of certain types of cancer, particularly colorectal cancer. 

"The most of us we dont know exactly how many adverse effects has this 'innocent' pill..."

"Cannabis & Alzheimer's Desease"

Alzheimer's disease (AD) is a neurological disorder of unknown origin that is characterized by a progressive loss of memory and learned behavior. For both patients and their loved ones, Alzheimer’s Disease ranks among the most challenging conditions one can experience.

This chronic neurodegenerative disorder leads to progressive symptoms including dementia, memory loss, emotional issues, and speech problems, among others. Few treatments exist and available therapies only address some symptoms, but not the progression of the disease itself.

The search for new therapeutic options has led to significant interest in cannabis-based treatments and researchers are currently working to advance our understanding of the possible roles medical cannabis could play in the future of Alzheimer’s treatment.

Preclinical data shows the potential of cannabinoids to moderate the progression of AD while clinical data demonstrates that these compounds can provide symptom relief, but lets take a look in what 10 studies says about it...

"CBD & Coconut Oil... An ultimate healing combine"

Perhaps you have notise that in the health industry there is an emphasis on combine CBD and coconut oil... And there is an excellent reason for this... 

"Our bodies to properly digest and absorb nutrients, must break down and absorb compounds via the intestinal wall and here is where this combination make the differense"

But before we look at why these two oils make such a great couple, lets take a closely look at some of the health benefits of each one separate.

About Coconut Oil...

Coconut oil is widely marketed as a superfood and there is a good reason for this.
The unique combination of fatty acids in coconut oil may have positive effects on our health, such as boosting fat loss, heart health, and brain function.
Here are some of the most popular health benefits of coconut oil: 

1. Antibiotic
2. Anti-viral
3. Antibacterial Properties
4. Improves Cholesterol
5. Improves Cognitive Function
6. Improves Digestion
7. Promotes Healthy Skin
8. Reduces Inflammation
9. Provides Energy

"CBD & Liver Disorders"

Probably you'll have heard about an article in Forbes,  with title "CBD can cause liver damage"... 

Actually the article claims that CBD “could be damaging our livers in the same way as alcohol and other drugs." ... the evidense was taken by a study from researchers at the University of Arkansas in Little Rock.

Of course, they never mention that the drug that the researchers used was the EPIDIOLEX, wich is a prescription medicine that is used to treat seizures associated with Lennox-Gastaut syndrome or Dravet syndrome in patients 2 years of age and older. 

Also the doses was extremely higher than the normal (20mg/kg)...

"Animals were gavaged with either 0, 246, 738, or 2460 mg/kg of CBD or with daily doses of 0, 61.5, 184.5, or 615 mg/kg for 10 days. A dose of 246 mg/kg was chosen as an initial dose as this is a MED analogous to those used in recent clinical trials (MED of 20 mg/kg CBD). 

Subsequently, researchers used doses of 738 and 2460 mg/kg CBD as 3× and 10× doses, respectively. Finally they demonstrated that CBD, when delivered orally to mice in the form of a concentrated CBD-enriched Cannabis extract, has the potential to cause liver injury...

So, on the basis of such an inaccurate article, we thought about doing our own research on CBD and the potential benefits it may have to the liver-related diseases...

"New Studies Reveals That Cannabis Helps PTSD Patients"

Post-traumatic stress disorder (PTSD) is a mental disorder that can develop after a person is exposed to a traumatic event.

This debilitating condition causes chronic problems like nightmares, panic attacks, hypervigilance, detachment from others, overwhelming emotions, and self-destructive behavior.

Unfortunatelly these overwhelming symptoms can even lead to suicide.

The current method of treating PTSD is to medicate the symptoms, not to actually treat the patient. In fact, many of the medications prescribed do the opposite and suppress the brain’s natural healing functions.

Because of this, many PTSD patients are stuck in a cycle: take pills, feel sedated, stop taking pills, then feel alive until the massive hammer of symptoms comes back. This is why we see so many veterans taking their own lives – not to mention the number of first responders who are suffering and who rarely get discussed.

Many PTSD patients have been saying for years that cannabis helps with their PTSD.

 

Previous research has shown that cannabis has the potential to reduce anxiety, or even prevent heightened anxiety in threatening situations. But up to this point, no studies had investigated this response in adults dealing with trauma - such as those with PTSD. 

Two new studies point to the way that cannabinoids may help treat PTSD. One shows how cannabis can reduce activity in the amygdala (part of the brain associated with fear responses to threats) andd the other suggests that the plant’s cannabinoids could play a role in extinguishing traumatic memories. Both effects could be therapeutic for those suffering from PTSD - according to those studies.

"The Antimicrobial Activities of Phytocannabinoids"

Novel antimicrobial drugs are urgently needed to counteract the increasing occurrence of bacterial resistance. 

Extracts of Cannabis sativa have been used for the treatment of several diseases since ancient times. 

It has been demonstrated that several cannabinoids show potent antimicrobial activity against primarily Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA). As first in vivo efficacy has been demonstrated recently, it is time to discuss whether cannabinoids are promising antimicrobial drug candidates or overhyped intoxicants with benefits.

The worldwide spread of bacterial resistance against market antibiotics has been identified as one of the major threats to public health by scientists and healthcare authorities. Thus, new antibacterial strategies and antibacterial compounds are urgently needed to counteract the increasing occurrence of antibiotic-resistant and, especially, multidrug-resistant (MDR) pathogens, to keep the live-saving advantages toward bacterial pathogens. 

In 2017, the World Health Organization (WHO) emphasized the crucial need for antimicrobial drug development against a group of 13 different genii, families, and specific species of pathogenic bacteria.The real problem is that the vast majority of these prioritized bacterial pathogens are drug-resistant Gram-negative bacteria.

However, antimicrobial resistances are also increasing in Gram-positive bacteria and, among the high priority pathogens, the Gram-positive pathogen Staphylococcus aureus is the leading cause of both healthcare and community-associated infections worldwide, and a major cause for morbidity as well as mortality.

"CBD Improves Blood Flow to Brain’s Hippocampus"

Cannabidiol (CBD) increases cerebral blood flow to areas of the brain associated with memory processing, specifically the hippocampus. The findings identify a potential mechanism for the use of CBD to treat disorders associated with altered memory processing, including Alzheimer’s disease, PTSD, and schizophrenia.

A single dose of cannabidiol (CBD) helped increase blood flow to the hippocampus, an important area of the brain associated with memory and emotion, finds a new study led by UCL researchers.

Researchers say the findings could be an important discovery for conditions which affect memory, such as Alzheimer’s disease and post-traumatic stress disorder (PTSD), and could help better target therapies.

In the study, published in the Journal of Psychopharmacology, researchers set out to investigate how CBD influences cerebral blood flow in different regions on the brain involved in memory processing.

Lead author, Dr Michael Bloomfield (UCL Psychiatry) said: “Cannabidiol is one of the main constituents of cannabis and is gaining interest for its therapeutic potential.

"Using CBD to Treat the Symptoms of Alzheimer’s & Other Forms of Dementia"

Worldwide, 50 million people are living with Alzheimer's and other dementias.

Alzheimer’s disease is a degenerative brain disease and the most common form of dementia. 

Dementia its an overall term that describes a group of symptoms.

Dementia is a general term for loss of memory, language, problem-solving and other thinking abilities that are severe enough to interfere with daily life. Alzheimer's is the most common cause of dementia.

The dementia-related conditions that can be helped by CBD include: Alzheimer’s disease, Vascular Dementia, Dementia with Lewy bodies (DLB), Parkinson’s disease, Frontotemporal dementia and Huntington’s disease.

According to researchers at California’s Salk Institute, their 2017 study has found evidence that cannabinoids such as CBD could help remove dementia from, and increase connections between, brain cells. Those results were validated by other laboratories. 

There are three ways CBD can work to improve health outcomes for persons with dementia: by reducing inflammation, by reducing oxygen buildup, and by working as a brain stimulant and neuroprotectant. From a user’s perspective, CBD may reduce stress and anxiety in the individual with dementia as well as reduce the decline of memory and other brain functions.

"Safety and efficacy of cannabidiol in children and adults with treatment resistant Lennox-Gastaut syndrome or Dravet syndrome"

Since 2014, patients with severe treatment-resistant epilepsies (TREs) have been receiving add-on cannabidiol (CBD) in an ongoing, expanded access program (EAP), which closely reflects clinical practice.

Researchers conducted an interim analysis of long-term efficacy and tolerability in patients with Lennox-Gastaut syndrome (LGS) or Dravet syndrome (DS) who received CBD treatment through December 2016.

The Study...

Children and adults with LGS/DS taking stable doses of antiepileptic drugs (AEDs) at baseline were included from 25 EAP sites across the United States.

During the 4-week baseline period, parents/caregivers kept diaries of all countable seizure types. Patients received a pharmaceutical formulation of highly purified CBD in oral solution at 2-10 mg/kg/day, titrated until tolerability limit or a maximum dose of 25-50 mg/kg/day.

"CBD and Epilepsy"

Epilepsy is a common neurologic disorder, it is estimated that ∼50 million people are affected worldwide. 

About one third of those patients are drug resistant, defined as failure to stop all seizures despite adequate trials of at least 2 appropriate medications.

CBD (cannabidiol) has been shown to be an effective treatment for epilepsy, particularly in reducing the frequency and severity of seizures in people with certain types of epilepsy.

In 2018, the FDA approved a CBD-based medication called Epidiolex for the treatment of two rare forms of childhood epilepsy, Lennox-Gastaut syndrome and Dravet syndrome. Clinical trials showed that Epidiolex significantly reduced the number of seizures in patients with these conditions.

CBD works by interacting with the body's endocannabinoid system, which plays a role in regulating various bodily functions, including mood, pain, and sleep. It is thought that CBD may help to reduce seizures by interacting with certain receptors in the brain and nervous system.

There has been an enormous interest in developing antiepileptic drugs with novel mechanisms of action. This review discusses the evidence supporting the anticonvulsant properties of cannabis in humans, focusing on cannabidiol.

"CBD could help people quit cannabis bad habit"

A benchmark clinical trial published on 28/07/2020 shows that cannabidiol (CBD) could be a safe and effective treatment for problematic cannabis use. 

Results from the first-ever randomised clinical trial of CBD for cannabis use disorder suggests that prescribed doses of the non-intoxicating constituent part of the cannabis plant could help people kick the habit.

In the MRC-funded trial, published in the Lancet Psychiatry, researchers administered doses of CBD or placebo to 82 volunteers who were motivated to quit using cannabis but had previously failed to do so. They measured the effects of the drug on levels of cannabis use both during a four-week treatment period and up to six months follow-up.

As this was the first clinical trial to assess CBD for reducing cannabis use, they tested three different doses of CBD in an adaptive design to find out which doses might be most effective.

• In the first stage of the trial, 48 volunteers received either placebo or CBD at doses of 200mg, 400mg or 800mg. The researchers found that the lowest dose of 200mg CBD was ineffective and so they dropped it from the trial.
• In the second stage of the trial, the researchers recruited an additional 34 volunteers to receive either placebo, 400mg or 800mg CBD. At the end of the trial, they found consistent evidence that CBD at 400mg or 800mg was more effective than placebo at reducing cannabis use.