"Beyond the CB1 & CB2... The Therapeutic Promise of TRPV1 & GPR55 Receptors"

If you’re familiar with cannabis science, you know about CB1 and CB2, the receptors located throughout the body that are triggered by cannabinoids like tetrahydrocannabinol (THC) and cannabidiol (CBD). 
It’s via these receptors that THC and CBD are able to bring about some of the therapeutic effects that cannabis is known for.

While CB1 and CB2 get the most attention—likely because we know the most about them—there are other receptors in the body that also respond to cannabinoids, like TRPV1 and GPR55. These receptors are influenced by THC and CBD, as well as anandamide and 2-arachidonoylglycerol (2-AG), endocannabinoids made by our bodies.

"Research on the TRPV1 and GPR55 receptors shows cannabinoids may hold promise in treating cancer and Dravet syndrome".

We’re beginning to gain a better understanding of TRPV1 and GPR55. Both hold much therapeutic promise, and CBD may be one of the ways to unlock this potential.

"A BRAVE YOUNG GIRL WITH A UNIQUE & INSPIRING PATH THROUGH CHILDHOOD LEUKEMIA"

"Some may say that cannabis does not “cure” cancer…

I am not saying the steroids and chemo didn’t help…
but all this right here shows something…
proof enough for me!

Some say cannabis is inappropriate for children…
We say cancer is inappropriate for children..."


This is the story of a little girl Mykayla that on July14th 2012, diagnosed with T-cell Acute Lymphoblastic Leukemia (ALL)
​
Leukemia is cancer of the blood and bone marrow.
Acute Lymphoblastic Leukemia (ALL) is a very rare and aggressive form of childhood leukemia, it accounts for 15-18% of childhood leukemia cases.

-In a healthy child, the bone marrow makes blood stem cells (immature cells) that become mature blood cells over time. A blood stem cell may become a myeloid stem cell or a lymphoid stem cell.

-In a child with ALL, too many stem cells become lymphoblasts, B lymphocytes, or T lymphocytes. The cells do not work like normal lymphocytes and are not able to fight infection very well. These cells are cancer leukemia cells.

"Cannabidiol Significantly Reduces Seizures in Patients with Severe Form of Epilepsy"

Researchers provide further evidence that the cannabis compound, CBD, is effective at reducing seizures in people with epilepsy. The new study reveals CBD significantly reduced seizures in people with Lennox-Gastaut syndrome. Previously, the researchers demonstrated CBD was effective at seizure control in Dravet syndrome.

Cannabidiol (CBD), a compound derived from the cannabis plant that does not produce a “high” and has been an increasing focus of medical research, was shown in a new large-scale, randomized, controlled trial to significantly reduce the number of dangerous seizures in patients with a severe form of epilepsy called Lennox–Gastaut syndrome.

"Cannabidiol could help deliver medications to the brain"

Cannabidiol (CBD), a non-psychoactive compound in cannabis, is being touted as beneficial for many health conditions, ranging from anxiety to epilepsy.

Although much more research is needed to verify these claims, scientists have now shown that CBD could have a different use as a "Trojan horse": helping slip medications across the blood-brain barrier (BBB).

The researchers report their results in the ACS journal Molecular Pharmaceutics.

The BBB consists of a layer of tightly linked cells that line capillaries in the brain, preventing substances from exiting the blood and entering the brain. However, the BBB does permit some molecules to pass, such as glucose and certain amino acids and neurotransmitters. For example, a class of neurotransmitters called endocannabinoids bind to proteins called cannabinoid receptors in the BBB, and the receptors help transport the molecules across the barrier and into the brain.

"Evidence for Therapeutic Properties of CBD/THC in Alzheimer's Disease"

Alzheimer's Disease (AD) is a debilitating neurodegenerative disease that is characterized by cognitive decline.

It is the most common form of dementia,accounting for over 60% of cases and affecting over 33 million people worldwide.


Unfortunately the current approved AD treatments only provide limited therapeutic benefits.

There are four approved drugs available, but unfortunately, all of them have been associated with adverse effects. Acetylcholinesterase inhibitors may cause nausea, vomiting, diarrhea and weight loss, while memantine is known to cause hallucinations, dizziness and fatigue.Furthermore, none of these treatments prevent or reverse the progression of the disease but rather they treat the disease symptoms with limited efficacy

Cannabidiol (CBD) is a non-psychoactive phytocannabinoid that has demonstrated neuroprotective, anti-inflammatory and antioxidant properties. It is investigated as a potential multifunctional treatment option for AD.

Here, we summarize the current status quo of effects of CBD in established pharmacological and transgenic animal models for AD.The phytocannabinoid cannabidiol (CBD) is a prime candidate for this new treatment strategy.

The in vivo therapeutic potential of CBD in AD has not been widely documented, however, there are a number of studies that have reported the effect of CBD in pharmacological models of AD. These studies have described anti-inflammatory and neuroprotective effects of CBD.