"Israeli Researchers Probe How Cannabis Can Treat Endometriosis"

Israeli researchers have started pre-clinical studies to examine the impact of medical cannabis in the treatment of endometriosis, a medical problem that affects one in 10 women of childbearing age.

The research is led by Gynica, which is licensed by the Health Ministry to develop cannabis-based products for women, in cooperation with Lumir Lab, a cannabis research facility in the Biotechnology Park, Hadassah Ein Karem, Jerusalem.

Endometriosis affects some 176 million women worldwide. In affected women, uterine lining grows outside the uterus, in the fallopian tubes, ovaries and other areas of the abdominal cavity and in the pelvis. These women suffer from severe pain before and during menstruation, bleeding and pain during and after intercourse, dyspepsia and frequent or painful urination.

Anecdotal evidence has shown that women who smoke cannabis find relief from their pain, said Dr. Sari Sagiv, VP of research and development at Gynica. The researchers set out to find out what compounds or combination of compounds of cannabis can potentially address the problem.

"Beyond the CB1 & CB2... The Therapeutic Promise of TRPV1 & GPR55 Receptors"

If you’re familiar with cannabis science, you know about CB1 and CB2, the receptors located throughout the body that are triggered by cannabinoids like tetrahydrocannabinol (THC) and cannabidiol (CBD). 
It’s via these receptors that THC and CBD are able to bring about some of the therapeutic effects that cannabis is known for.

While CB1 and CB2 get the most attention—likely because we know the most about them—there are other receptors in the body that also respond to cannabinoids, like TRPV1 and GPR55. These receptors are influenced by THC and CBD, as well as anandamide and 2-arachidonoylglycerol (2-AG), endocannabinoids made by our bodies.

"Research on the TRPV1 and GPR55 receptors shows cannabinoids may hold promise in treating cancer and Dravet syndrome".

We’re beginning to gain a better understanding of TRPV1 and GPR55. Both hold much therapeutic promise, and CBD may be one of the ways to unlock this potential.

"A BRAVE YOUNG GIRL WITH A UNIQUE & INSPIRING PATH THROUGH CHILDHOOD LEUKEMIA"

"Some may say that cannabis does not “cure” cancer…

I am not saying the steroids and chemo didn’t help…
but all this right here shows something…
proof enough for me!

Some say cannabis is inappropriate for children…
We say cancer is inappropriate for children..."


This is the story of a little girl Mykayla that on July14th 2012, diagnosed with T-cell Acute Lymphoblastic Leukemia (ALL)
​
Leukemia is cancer of the blood and bone marrow.
Acute Lymphoblastic Leukemia (ALL) is a very rare and aggressive form of childhood leukemia, it accounts for 15-18% of childhood leukemia cases.

-In a healthy child, the bone marrow makes blood stem cells (immature cells) that become mature blood cells over time. A blood stem cell may become a myeloid stem cell or a lymphoid stem cell.

-In a child with ALL, too many stem cells become lymphoblasts, B lymphocytes, or T lymphocytes. The cells do not work like normal lymphocytes and are not able to fight infection very well. These cells are cancer leukemia cells.

"Cannabidiol Significantly Reduces Seizures in Patients with Severe Form of Epilepsy"

Researchers provide further evidence that the cannabis compound, CBD, is effective at reducing seizures in people with epilepsy. The new study reveals CBD significantly reduced seizures in people with Lennox-Gastaut syndrome. Previously, the researchers demonstrated CBD was effective at seizure control in Dravet syndrome.

Cannabidiol (CBD), a compound derived from the cannabis plant that does not produce a “high” and has been an increasing focus of medical research, was shown in a new large-scale, randomized, controlled trial to significantly reduce the number of dangerous seizures in patients with a severe form of epilepsy called Lennox–Gastaut syndrome.

"Cannabidiol could help deliver medications to the brain"

Cannabidiol (CBD), a non-psychoactive compound in cannabis, is being touted as beneficial for many health conditions, ranging from anxiety to epilepsy.

Although much more research is needed to verify these claims, scientists have now shown that CBD could have a different use as a "Trojan horse": helping slip medications across the blood-brain barrier (BBB).

The researchers report their results in the ACS journal Molecular Pharmaceutics.

The BBB consists of a layer of tightly linked cells that line capillaries in the brain, preventing substances from exiting the blood and entering the brain. However, the BBB does permit some molecules to pass, such as glucose and certain amino acids and neurotransmitters. For example, a class of neurotransmitters called endocannabinoids bind to proteins called cannabinoid receptors in the BBB, and the receptors help transport the molecules across the barrier and into the brain.