"Neuroprotective Effects Of Cannabis" by Sensi Seed

Following on from our recent article on the relationship between cannabis use and stroke, we now investigate the role of cannabinoids in mitigating brain damage caused by traumatic brain injury and ischemic stroke. There is mounting evidence to suggest that their various properties have great therapeutic potential.

-Antioxidative & anti-inflammatory properties

In recent years the evidence for the antioxidative and anti-inflammatory properties of various cannabinoids has become well-established, and our understanding of the role they play in modulating neurotransmission too has grown. Thus, serious consideration is now being given to their potential as neuroprotective agents. Cannabinoids have been shown to prevent neuronal death in acute neuronal injury, including Ischemic Stroke (IS) and Traumatic Brain Injury (TBI), as well as provide symptomatic relief in Multiple Sclerosis (MS), Huntington’s disease, and other chronic neurodegenerative diseases.

"Using CBD to Treat the Symptoms of Alzheimer’s & Other Forms of Dementia"

Worldwide, 50 million people are living with Alzheimer's and other dementias.

Alzheimer’s disease is a degenerative brain disease and the most common form of dementia. 

Dementia its an overall term that describes a group of symptoms.

Dementia is a general term for loss of memory, language, problem-solving and other thinking abilities that are severe enough to interfere with daily life. Alzheimer's is the most common cause of dementia.

The dementia-related conditions that can be helped by CBD include: Alzheimer’s disease, Vascular Dementia, Dementia with Lewy bodies (DLB), Parkinson’s disease, Frontotemporal dementia and Huntington’s disease.

According to researchers at California’s Salk Institute, their 2017 study has found evidence that cannabinoids such as CBD could help remove dementia from, and increase connections between, brain cells. Those results were validated by other laboratories. 

There are three ways CBD can work to improve health outcomes for persons with dementia: by reducing inflammation, by reducing oxygen buildup, and by working as a brain stimulant and neuroprotectant. From a user’s perspective, CBD may reduce stress and anxiety in the individual with dementia as well as reduce the decline of memory and other brain functions.

"Can CBD help With Neuroinflammation"

Neuroinflammation is an inflammatory condition of the brain, in which glial cells,namely,astrocytes 
and microglia,the resident macrophages of the brain, are involved along with blood-borne cells. 

Although in the past glial activation in neuroinflammation has been considered detrimental to the brain in general, currently the reparative/ protective aspects are being recognized. 

Cannabinoids, whether plant derived or endogenous  affect different glial functions. 

Importantly, glial cells are endowed with several, if not all, of the elements of the endocannabinoid system, and therefore are sensitive to cannabinoids and at the same time are a source of endocannabinoids. 

There appears to be general agreement that cannabinoids reduce the synthesis, production, and release of cytotoxic molecules such as proinflammatory cytokines and nitric oxide. 

On the other hand, these agents modify microglial cell migration in such a way that the result is usually beneficial in resolving neuroinflammation or limiting ensuing neurodegeneration.